Lymphatic Filariasis: Perspectives on Lymphatic Remodeling and Contractile Dysfunction in Filarial Disease Pathogenesis
Identifieur interne : 003B18 ( Main/Exploration ); précédent : 003B17; suivant : 003B19Lymphatic Filariasis: Perspectives on Lymphatic Remodeling and Contractile Dysfunction in Filarial Disease Pathogenesis
Auteurs : Sanjukta Chakraborty [États-Unis] ; Manokaran Gurusamy [Inde] ; David C. Zawieja [États-Unis] ; Mariappan Muthuchamy [États-Unis]Source :
- Microcirculation [ 1073-9688 ] ; 2013-07.
Descripteurs français
- KwdFr :
- Animaux, Filariose lymphatique (anatomopathologie), Filariose lymphatique (physiopathologie), Humains, Intestins (parasitologie), Intestins (physiopathologie), Néovascularisation pathologique (anatomopathologie), Néovascularisation pathologique (parasitologie), Néovascularisation pathologique (physiopathologie), Système lymphatique (anatomopathologie), Système lymphatique (parasitologie), Système lymphatique (physiopathologie), Transport biologique actif, Wuchereria.
- MESH :
- anatomopathologie : Filariose lymphatique, Néovascularisation pathologique, Système lymphatique.
- parasitologie : Intestins, Néovascularisation pathologique, Système lymphatique.
- physiopathologie : Filariose lymphatique, Intestins, Néovascularisation pathologique, Système lymphatique.
- Animaux, Humains, Transport biologique actif, Wuchereria.
English descriptors
- KwdEn :
- Animals, Biological Transport, Active, Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (physiopathology), Humans, Intestines (parasitology), Intestines (physiopathology), Lymphatic System (parasitology), Lymphatic System (pathology), Lymphatic System (physiopathology), Neovascularization, Pathologic (parasitology), Neovascularization, Pathologic (pathology), Neovascularization, Pathologic (physiopathology), Wuchereria.
- MESH :
- parasitology : Intestines, Lymphatic System, Neovascularization, Pathologic.
- pathology : Elephantiasis, Filarial, Lymphatic System, Neovascularization, Pathologic.
- physiopathology : Elephantiasis, Filarial, Intestines, Lymphatic System, Neovascularization, Pathologic.
- Animals, Biological Transport, Active, Humans, Wuchereria.
Abstract
Lymphatic filariasis, one of the most debilitating diseases associated with the lymphatic system, affects over a hundred million people worldwide and manifests itself in a variety of severe clinical pathologies. The filarial parasites specifically target the lymphatics and impair lymph flow, which is critical for the normal functions of the lymphatic system in maintenance of body fluid balance and physiological interstitial fluid transport. The resultant contractile dysfunction of the lymphatics causes fluid accumulation and lymphedema, one of the major pathologies associated with filarial infection. In this review, we take a closer look at the contractile mechanisms of the lymphatics, its altered functions, and remodeling during an inflammatory state and how it relates to the severe pathogenesis underlying a filarial infection. We further elaborate on the complex host–parasite interactions, and molecular mechanisms contributing to the disease pathogenesis. The overall emphasis is on elucidating some of the emerging concepts and new directions that aim to harness the process of lymphangiogenesis or enhance contractility in a dysfunctional lymphatics, thereby restoring the fluid imbalance and mitigating the pathological conditions of lymphatic filariasis.
Url:
- https://api.istex.fr/document/0EA6A92BD8445DF1CCCF342258069AC7B8043F1F/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613430
DOI: 10.1111/micc.12031
Affiliations:
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Le document en format XML
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The filarial parasites specifically target the lymphatics and impair lymph flow, which is critical for the normal functions of the lymphatic system in maintenance of body fluid balance and physiological interstitial fluid transport. The resultant contractile dysfunction of the lymphatics causes fluid accumulation and lymphedema, one of the major pathologies associated with filarial infection. In this review, we take a closer look at the contractile mechanisms of the lymphatics, its altered functions, and remodeling during an inflammatory state and how it relates to the severe pathogenesis underlying a filarial infection. We further elaborate on the complex host–parasite interactions, and molecular mechanisms contributing to the disease pathogenesis. The overall emphasis is on elucidating some of the emerging concepts and new directions that aim to harness the process of lymphangiogenesis or enhance contractility in a dysfunctional lymphatics, thereby restoring the fluid imbalance and mitigating the pathological conditions of lymphatic filariasis.</div></front></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Chakraborty, Sanjukta" sort="Chakraborty, Sanjukta" uniqKey="Chakraborty S" first="Sanjukta" last="Chakraborty">Sanjukta Chakraborty</name></noRegion><name sortKey="Muthuchamy, Mariappan" sort="Muthuchamy, Mariappan" uniqKey="Muthuchamy M" first="Mariappan" last="Muthuchamy">Mariappan Muthuchamy</name><name sortKey="Muthuchamy, Mariappan" sort="Muthuchamy, Mariappan" uniqKey="Muthuchamy M" first="Mariappan" last="Muthuchamy">Mariappan Muthuchamy</name><name sortKey="Zawieja, David C" sort="Zawieja, David C" uniqKey="Zawieja D" first="David C." last="Zawieja">David C. Zawieja</name></country><country name="Inde"><noRegion><name sortKey="Gurusamy, Manokaran" sort="Gurusamy, Manokaran" uniqKey="Gurusamy M" first="Manokaran" last="Gurusamy">Manokaran Gurusamy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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